Near-Infrared Properties of Faint X-rays Sources from NICMOS Imaging in the Chandra Deep Fields

We measure the near-infrared properties of 42 X-ray detected sources from the Chandra Deep Fields North and South, the majority of which lie within the NICMOS Hubble Deep Field North and Ultra Deep Field. We detect all 42 Chandra sources with NICMOS, with 95% brighter than H = 24.5. We find that X-ray sources are most often in the brightest and most massive galaxies. Neither the X-ray fluxes nor hardness ratios of the sample show any correlation with near-infrared flux, color or morphology. This lack of correlation indicates there is little connection between the two emission mechanisms and is consistent with the near-infrared emission being dominated by starlight rather than a Seyfert non-stellar continuum. Near-infrared X-ray sources make up roughly half of all extremely red (J-H > 1.4) objects brighter than H > 24.5. These red X-ray sources have a range of hardness ratios similar to the rest of the sample, decreasing the likelihood of dust-obscured AGN activity as the sole explanation for their red color. Using a combination of spectroscopic and photometric redshifts, we find the red J-H objects are at high redshifts (z > 1.5), which we propose as the primary explanation for their extreme J-H color. Measurement of rest-wavelength absolute B magnitudes shows that X-ray sources are the brightest optical objects at all redshifts, which explains their dominance of the bright end of the red J-H population.Comment: 29 pages, 7 figures, accepted by Ap

A Deep HST Search for Escaping Lyman Continuum Flux at z~1.3: Evidence for an Evolving Ionizing Emissivity

We have obtained deep Hubble Space Telescope far-UV images of 15 starburst galaxies at z~1.3 in the GOODS fields to search for escaping Lyman continuum photons. These are the deepest far-UV images m_{AB}=28.7, 3\sigma, 1" diameter) over this large an area (4.83 arcmin^2) and provide the best escape fraction constraints for any galaxy at any redshift. We do not detect any individual galaxies, with 3\sigma limits to the Lyman Continuum (~700 \AA) flux 50--149 times fainter (in f_nu) than the rest-frame UV (1500 \AA) continuum fluxes. Correcting for the mean IGM attenuation (factor ~2), as well as an intrinsic stellar Lyman Break (~3), these limits translate to relative escape fraction limits of f_{esc,rel}<[0.03,0.21]. The stacked limit is f_{esc,rel}(3\sigma)<0.02. We use a Monte Carlo simulation to properly account for the expected distribution of IGM opacities. When including constraints from previous surveys at z~1.3 we find that, at the 95% confidence level, no more than 8% of star--forming galaxies at z~1.3 can have relative escape fractions greater than 0.50. Alternatively, if the majority of galaxies have low, but non-zero, escaping Lyman Continuum, the escape fraction can not be more than 0.04. Both the stacked limits, and the limits from the Monte Carlo simulation suggest that the average ionizing emissivity (relative to non-ionizing UV emissivity) at z~1.3 is significantly lower than has been observed in Lyman Break Galaxies (LBGs) at z~3. If the ionizing emissivity of star-forming galaxies is in fact increasing with redshift, it would help to explain the high photoionization rates seen in the IGM at z>4 and reionization of the intergalactic medium at z>6. [Abridged]Comment: Submitted to ApJ (Nov. 6) Comments Welcome. 11 pages, 8 figure

A Lyman Break Galaxy Candidate at z~9

We report the discovery of a z~9 Lyman Break Galaxy (LBG) candidate, selected from the NICMOS Parallel Imaging Survey as a J-dropout with J110 - H160 = 1.7. Spitzer/IRAC photometry reveals that the galaxy has a blue H160 - 3.6 um color, and a spectral break between 3.6 and 4.5 um. We interpret this break as the Balmer break, and derive a best-fit photometric redshift of z~9. We use Monte Carlo simulations to test the significance of this photometric redshift, and show a 96% probability of z>7. We estimate a lower limit to the comoving number density of such galaxies at z~9 of phi > 3.8 x 10^{-6} Mpc^{-3}. If the high redshift of this galaxy is confirmed, this will indicate that the luminous end of the rest-frame UV luminosity function has not evolved substantially from z~ 9 to z~3. Still, some small degeneracy remains between this z~9 model and models at z~2-3; deep optical imaging (reaching I ~ 29 AB) can rule out the lower-z models.Comment: Accepted to ApJ Letter

LSST Science Book, Version 2.0

A survey that can cover the sky in optical bands over wide fields to faint magnitudes with a fast cadence will enable many of the exciting science opportunities of the next decade. The Large Synoptic Survey Telescope (LSST) will have an effective aperture of 6.7 meters and an imaging camera with field of view of 9.6 deg^2, and will be devoted to a ten-year imaging survey over 20,000 deg^2 south of +15 deg. Each pointing will be imaged 2000 times with fifteen second exposures in six broad bands from 0.35 to 1.1 microns, to a total point-source depth of r~27.5. The LSST Science Book describes the basic parameters of the LSST hardware, software, and observing plans. The book discusses educational and outreach opportunities, then goes on to describe a broad range of science that LSST will revolutionize: mapping the inner and outer Solar System, stellar populations in the Milky Way and nearby galaxies, the structure of the Milky Way disk and halo and other objects in the Local Volume, transient and variable objects both at low and high redshift, and the properties of normal and active galaxies at low and high redshift. It then turns to far-field cosmological topics, exploring properties of supernovae to z~1, strong and weak lensing, the large-scale distribution of galaxies and baryon oscillations, and how these different probes may be combined to constrain cosmological models and the physics of dark energy.Comment: 596 pages. Also available at full resolution at http://www.lsst.org/lsst/sciboo

CEERS: Spatially Resolved UV and mid-IR Star Formation in Galaxies at 0.2 < z < 2.5: The Picture from the Hubble and James Webb Space Telescopes

We present the mid-IR (MIR) morphologies for 64 star-forming galaxies at 0.210^{9}~M_\odot} using JWST MIRI observations from the Cosmic Evolution Early Release Science survey (CEERS). The MIRI bands span the MIR (7.7--21~$\mu$m), enabling us to measure the effective radii ($R_{\rm{eff}}$) and S\'{e}rsic indexes of these SFGs at rest-frame 6.2 and 7.7 $\mu$m, which contains strong emission from Polycyclic aromatic hydrocarbon (PAH) features, a well-established tracer of star formation in galaxies. We define a ``PAH-band'' as the MIRI bandpass that contains these features at the redshift of the galaxy. We then compare the galaxy morphologies in the PAH-bands to those in rest-frame Near-UV (NUV) using HST ACS/F435W or ACS/F606W and optical/near-IR using HST WFC3/F160W imaging from UVCANDELS and CANDELS, where the NUV-band and F160W trace the profile of (unobscured) massive stars and the stellar continuum, respectively. The $R_{\rm{eff}}$ of galaxies in the PAH-band are slightly smaller ($\sim$10\%) than those in F160W for galaxies with $\rm{M_*\gtrsim10^{9.5}~M_\odot}$ at $z\leq1.2$, but the PAH-band and F160W have a similar fractions of light within 1 kpc. In contrast, the $R_{\rm{eff}}$ of galaxies in the NUV-band are larger, with lower fractions of light within 1 kpc compared to F160W for galaxies at $z\leq1.2$. Using the MIRI data to estimate the $\rm{SFR_{\rm{IR}}}$ surface density, we find the correlation between the $\rm{SFR_{\rm{IR}}}$ surface density and stellar mass has a steeper slope than that of the $\rm{SFR_{\rm{UV}}}$ surface density and stellar mass, suggesting more massive galaxies having increasing amounts of obscured fraction of star formation in their inner regions. This paper demonstrates how the high-angular resolution data from JWST/MIRI can reveal new information about the morphology of obscured-star formation.Comment: 28 pages, 11 figures, Accepted by Ap

Susceptibility to chronic mucus hypersecretion, a genome wide association study

Background: Chronic mucus hypersecretion (CMH) is associated with an increased frequency of respiratory infections, excess lung function decline, and increased hospitalisation and mortality rates in the general population. It is associated with smoking, but it is unknown why only a minority of smokers develops CMH. A plausible explanation for this phenomenon is a predisposing genetic constitution. Therefore, we performed a genome wide association (GWA) study of CMH in Caucasian populations.Methods: GWA analysis was performed in the NELSON-study using the Illumina 610 array, followed by replication and metaanalysis in 11 additional cohorts. In total 2,704 subjects with, and 7,624 subjects without CMH were included, all current or former heavy smokers (&gt;= 20 pack-years). Additional studies were performed to test the functional relevance of the most significant single nucleotide polymorphism (SNP).Results: A strong association with CMH, consistent across all cohorts, was observed with rs6577641 (p = 4.25610(-6), OR = 1.17), located in intron 9 of the special AT-rich sequence-binding protein 1 locus (SATB1) on chromosome 3. The risk allele (G) was associated with higher mRNA expression of SATB1 (4.3610 29) in lung tissue. Presence of CMH was associated with increased SATB1 mRNA expression in bronchial biopsies from COPD patients. SATB1 expression was induced during differentiation of primary human bronchial epithelial cells in culture.Conclusions: Our findings, that SNP rs6577641 is associated with CMH in multiple cohorts and is a cis-eQTL for SATB1, together with our additional observation that SATB1 expression increases during epithelial differentiation provide suggestive evidence that SATB1 is a gene that affects CMH.</p

Nuclear Calcium Signaling Controls Expression of a Large Gene Pool: Identification of a Gene Program for Acquired Neuroprotection Induced by Synaptic Activity

Synaptic activity can boost neuroprotection through a mechanism that requires synapse-to-nucleus communication and calcium signals in the cell nucleus. Here we show that in hippocampal neurons nuclear calcium is one of the most potent signals in neuronal gene expression. The induction or repression of 185 neuronal activity-regulated genes is dependent upon nuclear calcium signaling. The nuclear calcium-regulated gene pool contains a genomic program that mediates synaptic activity-induced, acquired neuroprotection. The core set of neuroprotective genes consists of 9 principal components, termed Activity-regulated Inhibitor of Death (AID) genes, and includes Atf3, Btg2, GADD45β, GADD45γ, Inhibin β-A, Interferon activated gene 202B, Npas4, Nr4a1, and Serpinb2, which strongly promote survival of cultured hippocampal neurons. Several AID genes provide neuroprotection through a common process that renders mitochondria more resistant to cellular stress and toxic insults. Stereotaxic delivery of AID gene-expressing recombinant adeno-associated viruses to the hippocampus confers protection in vivo against seizure-induced brain damage. Thus, treatments that enhance nuclear calcium signaling or supplement AID genes represent novel therapies to combat neurodegenerative conditions and neuronal cell loss caused by synaptic dysfunction, which may be accompanied by a deregulation of calcium signal initiation and/or propagation to the cell nucleus